50 Cups of Coffee a Day Change Your DNA? (Or Exercising…)

DNAThere is almost no question in anyone’s mind anymore about the benefits which can be derived by exercising. We know it burns calories, reduces the risk or having a stroke and developing heart disease as well as reducing the risk of developing Type II diabetes. What most people don’t know, though, is that exercise can also help change your DNA. Yes, that’s right. What is even more astounding than this is that this process happens after a single 20 minute workout. The changes that occur are unlike those which occur from external stimuli such as toxic air or exposure to other carcinogens. Exercise literally changes your DNA from the inside out.

In a study carried out at the Karolinska Institute in Stockholm, Sweden, a team of scientists monitored the muscle changes which occurred because of the body’s adaptation to exercise. They enrolled 14 young women and men into their study and had them exercise on a bike which measured their maximum levels of activity. The difference in this study from others which were similar is that participants were also required to have some of their muscle cells biopsied both before and after participating in the survey.

change-your-dna-with-exercisingWhen comparing the biopsy samples, the scientists discovered that more genes had been turned on after the exercise on the bike. In addition, the DNA of the participants when compared to the control group was able to turn on certain genes. This is usually accomplished by the body placing limits on how much methylation occurs in certain cells. This is the way that your body knows how to engineer a liver, for example, from stem cells that might be programmed to produce a kidney.

The process of methylation also helps cells pump the nutrients they need and the enzymes required while you are working out. Each time you exercise, the more intense your workout is, the more methyl is pumped out. One way this happens is because your muscles adapt to what you are doing. This means, essentially, if you don’t use it, you will lose it.

In order to confirm the way the genes were expressing themselves, the scientists next explored the effect that calcium had on the entire body’s system. Why? Because when people perform intense exercise, the body naturally releases calcium and this triggers the muscles to contract. When the amount of calcium released is blocked the muscles will still contract but not as efficiently or effectively. After the scientists added caffeine to their lab dishes, they were able to restore the contractions. This proved that the caffeine could enhance the way methyl triggered contraction and thus activated the genes that helped the muscles contract.

caffeine-to-change-your-dnaAll that being said, however, the researchers definitely do not recommend that people drink caffeinated drinks instead of exercising. Anyone who wanted to replicate these results simply by drinking caffeine would have to consume a lethal dose of about 50 cups of coffee in one day. What this does mean, though, is that exercise is  form of medicine and that a means of altering your DNA in a way that is beneficial may just be a job or bike ride away.

So even though we all know that a zebra can’t change it’s stripes, we now know that humans can change their own DNA something that was unthinkable just a few years ago.  The key is to just get off the couch and do something — go for a run, walk on the treadmill, climb some stairs. It scarcely even matters just as long as you do it for a minimum of twenty minutes.

The study in Stockholm was confirmed by another study carried out in Great Britain in which study participants were told to attend three classes of either aerobics exercise or spinning per week. The study participants were all healthy young men and women averaging about 24 years of age. Additionally, participants were told NOT to make any changes to either their diet or their normal daily activity levels.

The researchers carefully monitored the methyl groups in the fat cells of the male participants. All cells in the body contain DNA because this is where all the basic genetic information is housed.

exercisingEpigenetics is what the study of changes in gene expression on a cellular level is called. During this study, epigeneticists were able to literally track the changes that normal cells and fat cells underwent after exercise. They were able to detect changes in approximately 7,000 different genes, or about 35% of the participant’s genetic makeup.

They also paid close attention to the genes which are linked to obesity and Type II diabetes and were able to detect changes in those genes as well. Because of this study, scientists were able to make a genetic map of the DNA methylome contained in fat cells.

While the long-lasting effects or normal, regular exercise are not understood fully, these studies conclusively show that there are more benefits to exercising on a regular basis than simply losing weight. This along with lifestyle changes can help people lose weight with much more confidence than they might have had in the past.

Epigenetics better explained in this video below:

Lipofuze – Insider Look at Side Effects, Results & Quality

There are thousands of different fat burning supplements available on the weight loss market today. With the advertising promoting those supplements it can be hard to know what works, what doesn’t, and what is actually dangerous to take. Fortunately, Lipofuze is a fairly straightforward supplement that can actually provide great results to most people.

Currently, Lipofuze is viewed as one of the top products, but the manufacturer has probably told you that if you are looking at a review of it here. Whether that is true or not, we can’t say, but the quality ingredients surely make it one to keep an eye on if you are in the market. Before you decide, though, you should make sure to take a look at the big picture and understand just what we are talking about here.

The Claim

Lipofuze claims to provide 10 pounds of fat loss each week. That is an incredibly lofty claim, which relies entirely on a combination of fat burning and appetite suppression. You might not lose 10 pounds a week thanks to Lipofuze, but you might have better results than most people.

Pros and Cons of Lipofuze

lipofuzeThere are several key ingredients in Lipofuze that allow it to lay claim to such stupendous results. These include things such as green tea extract and green coffee bean extract. Both of these things are helpful with weight loss. Many people also consider them to be healthy because they will specifically target your fat cells and speed up your body’s metabolism. Both of these things will help you lose some weight. Another key ingredient contained in Lipofuze is African Mango Extract. This fruit extract is also beginning to make a name for itself in the weight loss market. It helps to curb the appetite which is the biggest culprit when it comes to sabotaging a diet. After all, it is extremely difficult to lose weight if you’re hungry all the time.

One of the biggest downsides to Lipofuze, unlike with most other diet pills, is that it definitely requires a commitment to doing some exercise. Most people who resort to using diet pills are looking for a quick fix with no effort on their part required. So, if you’re going to use this product you will also need to get back to the basics of how a person really loses weight. I really don’t like using diet pills as a basic weight loss tool and have never resorted to using them though I have certainly done my share of fad or trendy diets in my lifetime. I think that the claims made by the manufacturer are just a little bit too good to be true. Remember the old saying, “If it sounds to good to be true, it probably is”? I think that’s definitely the case with this product.

The Ingredients In Lipofuze

Lipofuze has an incredible ingredients list that are all proven to assist in fat burning and weight loss. These are all worth taking an individual look at, though.

  • CoEnzyme Q10
    • This is also known as Vitamin Q. It is vital to the human body and supplementing your diet with it will help to improve your metabolism and regulate energy. By transporting fat into the body to be broken down, CQ10 takes complete charge over your metabolism. One of the best ways to improve your metabolism is to first manage the chemicals that are already in your body. In addition, however, it can also improve the function of the immune system and improve hypertension in people suffering from the early stages of the disorder.
  • Caffeine
    • Caffeine is one of the most tried and true fat burning supplements known to humankind. The vast majority of diet pills feature this as an ingredient, and for good reason. Caffeine raises your body temperature, increases your metabolism, and shreds the fat off of you.
  • African Mango Extract
    • This is also known as Irvingia Gagonensis. This plant is full of antioxidants, fiber, and plenty more that will work to greatly improve your health. Primarily, the fiber content is going to slow the absorption of your food and prevent your body from absorbing carbohydrates too quickly and storing them as fat. Blood sugar level is one of the most important things to get under control while you are losing weight and african mango extract deals with that issue quickly and effectively.
  • Green Tea Select
    • Green tea, despite centuries of use in Chinese medicine, is only recently being studied for its weight loss properties. EGCG, the polyphenol in green tea, was shown to increase metabolism by over 20% over a period of several hours. While other supplements contain polyphenols, green tea has a type that is easily absorbed by the body. In addition to the metabolism boost you will find that lower blood pressure and an improved immune system are quickly discovered.
  • Green Coffee Extract
    • Coffee is well known to aid in weight loss. A cup of black coffee in the morning does wonders for boosting your metabolism and green coffee beans are a great alternative that performs even better. These unroasted coffee beans contain much more chlorogenic acid when compared to their roasted counterparts. The Chlorogenic acid has been found to burn fat more than caffeine alone. In comparison to drinking coffee, green coffee beans have the ability to lower blood pressure and help your heart, rather than hurt it.

Are There Any Side Effects?

Of course every diet pill comes with side effects, they are unavoidable. Lipofuze has a list of possible side effects, but not too much that seems common. Sleeplessness, digestive tract problems, allergic reactions, hypertension, and anxiety are all possible, but depend on dosage and previous experience with diet pills.

You should always talk to your doctor before making decisions about diet pills, but there are a few conditions that are more important with Lipofuze. Prescription medication interactions are common with blood sugar medications, cholesterol medications, and blood thinners. In most cases, though, your doctor will make sure to cover all of the bases and warn you of anything like this.


As with all diet pills, getting something for nothing is almost impossible. Lipofuze is no different. With proper dietary changes, Lipofuze can help you lose an extra pound or two a week. With exercise as well, however, you can lose much more. In people with plenty of weight to lose, don’t rule out the possibility of losing 10 pounds a month.

The Verdict

In the end, Lipofuze is an above average diet pill that may or may not have a lot of promise. The ingredients are all proven to be effective and many people have had a lot of success. But as with most things, there is no such thing as a magic bullet. That’s certainly the case with weight loss anyway.

Indepth Review Of Apidexin – Does Success Come With Side Effects?

ApidexinApidexin has been voted as one of the best diet pills in the country 3 years in a row. While the bottle looks like something that you would find in a pharmacy, this diet pill is available over the counter and costs about the same as many other diet pills on the market. The results can vary, but most people find that they are very satisfied with it. The goal here is to give you a closer look at Apidexin and show you the actual ingredients used and results, rather than give another over-fluffed review that is all over the internet.

Apidexin Ingredients

There are a lot of different ingredients in Apidexin, many of which you might not be familiar with. Fortunately, though, the manufacturer’s website lists published studies on the various parts to give you an idea of their quality and effectiveness.

  • Vitamin B12
    • Vitamin B12 is one of the most essential vitamins for energy production. There isn’t much research into fat burning properties, but it is safe to assume that the more energy you have, the more motivation you will have to keep up your fat burning efforts. This is especially true if your diet is lacking B vitamins, which many are.
  • Caffeine
    • Caffeine, as many people have found, works great for losing weight. The stimulation that it provides causes your body to heat up and start using more calories than ever just to sustain itself. You will also find that you have a smaller appetite, meaning you will eat less and feel full for longer. You can read more about caffeine & weight loss here.
  • Raspberry Ketones
    • Raspberry ketones work to take control of the hormone that regulates fat storage. Many people find that diet alone just can’t get the job done because their body tries its best to hang onto fat. Raspberry ketones overcome that and force your body to create energy from fat, much like a ketogenic diet. This is one of the most popular diet pill ingredients right now!
  • Irvingia Gabonensis
    • Irvingia Gabonensis is really just the scientific name of African Mango. What this does is block the storage of fat and help to prevent the absorption of carbohydrates in an effort to help further your fat loss goals. This isn’t as common as things like caffeine or raspberry ketones, but it is finding its way into many people’s weight loss regimens today.
  • Fucoxanthin
    • Fucoxanthin gets rid of your stores of white adipose tissue. It comes from seaweed, or other sea vegetables and has been found to be highly effective. The benefit of supplements like this is that you don’t have to suffer the jitters of stimulants, but can achieve the same benefit. You can read more here.
  • Guggul EZ
    • Guggul helps your thyroid gland properly regulate your metabolism. Of the multiple types of Guggul, E and Z are the most active. For hundreds of years, it was a part of Ayurvedic medicine, but it has now caught on in the Western world. In many cases, people suffer from a thyroid problem that stops them from losing fat despite all of their efforts. With a supplement that works to stop that problem you can easily add another 1-2 pounds of fat loss a week.
  • Bioperine
    • Bioperine is very important here. This black pepper extract works wonders to increase the absorption of vitamins and nutrients. In the case of many supplements, very little of the actual active ingredients are absorbed by the body. Bioperine makes sure that you get every benefit of the supplements that you are taking.

Are There Any Side Effects To Be Worried About?

Overall, there isn’t anything in Apidexin that makes it have any more serious side effects than other diet pills on the market. Your health and dosage will determine how many negative effects you feel.

Guggul can cause a variety of digestive problems in some people. Vomiting, diarrhea, hiccups, and nausea are all reported, but these aren’t thought to be too common. There is also a potential for blood thinning in some people, or even liver problems, but these are even more rare.

Caffeine, as you have probably learned, can cause an increase in heart rate and blood pressure, along with headaches and restless sleep.

Irvingia gabonensis sports similar side effects as caffeine, although not as common.

In general, headaches, an increase in blood pressure, restlessness, and nausea are all side effects in any diet pill. Talk to your doctor to see if you are at risk for the other side effects listed. Even if you are however, it will be dependent on the dosage that you are taking. Many people decide to double the dosage to increase their effects, but that usually only leads to problems.

However keeping that in mind, here is what one of the testimonials from their official site:


“I was constantly putting on weight and wasn’t able to shed it off even with cardio. I usually weighed around 115 lbs.- 120 lbs. But I gained so much weight (36 lbs.). I found Apidexin and felt confident about the safety reviews so I tried it. I have been using Apidexin since January of 2012 and am now at 118 lbs.! There is a great suppression in my appetite, I have energy yet I do not feel ill after taking the tab. I felt results within the first two weeks and they were evident after roughly four weeks. I’m very happy to be back to me! Thank you!”

- Kay Charoenwong

The Verdict

Overall, Apidexin shows a lot of promise for people trying to lose a few extra pounds as they work towards their goal weight. According to the company, there is a 98% satisfaction rate. Whether or not you can trust the manufacturer or not, this is obviously a great list of ingredients. They all have proven track records and only a few side effects.

The thing that should really influence your decision here is your own health. If you have liver problems, heart conditions, or have trouble sleeping this might not be for you. In most cases, though, the side effects that you experience will be mild and only happen on occasion. If you are a healthy individual that just needs to lose a few pounds this remains a great option for you. Talk to your doctor, as you always should, and find out if there is any reason for you to worry. If not, buy a bottle of Apidexin today and start dropping all of the weight that you have always wanted to.